The Potential Biomark of Serious Psychosis:a Prospective,Case-controled Study

The Potential Biomark of Serious Psychosis: Including the Variation of Brain MRI, BDNF and Oxidative Stress-related Immunological Factors in Different Phases.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02202460

Enrollment

200

Registered

2014-07-29

Start date

2014-08-31

Completion date

2020-12-31

Last updated

2014-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Other Immunological States or Disorders

Brief summary

Patients suffer from Serious Psychosis may have variation in immunological factors,BDNF and MRI.

Detailed description

Patients suffer from Schizophrenia and Mood Disorders may have variation in immunological factors(TNF-α,IL-2,IL-6,IL-10,etc),BDNF and Brain MRI.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Diagnosis with Schizophrenia , Bipolar Disorder or Major Depression by DSM-5

Exclusion criteria

* Unstable physical conditions

Design outcomes

Primary

Measure	Time frame	Description
Oxidative Stress-related Immunological Factors	18 month	Blood test will be conducted every 3 month to assess the concentration of oxidative stress-related immunological factors including TNFα,TGFβ， MCP-1，IL-1α，IL-2，IL-6，IL-10，IL-12.

Secondary

Measure	Time frame	Description
BDNF	18 month	Collecting participants' blood every 3 month to assess the concentration of brain derived neurotrophic factor.

Other

Measure	Time frame	Description
Brain MRI	18 month	Brain MRI will be examined every 6 month or when onset syptoms are dramatically changed.

Countries

China

Contacts

Primary ContactRenrong Wu, PhD

wurenrong2013@163.com+86 15874179855

Outcome results