Calculated SAP, Circulation, Drug Dose
Conditions
Brief summary
Although induced hypertension decreased SVV and PPV,the influences of stroke volume variation and pulse pressure variation caused by phenylephrine,dopamine and ephedrine were unknown.
Detailed description
Pulse pressure variation (PPV) and stroke volume variation (SVV) during mechanical ventilation have been shown to be effective parameters to predict preload responsiveness. Although induced hypertension decreases PPV and SVV, the influences of phenylephrine, dopamine and ephedrine on PPV and SVV are unknown.
Interventions
OTHERInfluences of phenylephrine, dopamine and ephedrine on stroke volume variation and pulse pressure variation
This research mainly study the effect of clinical commonly used vasoconstrictor drugs on blood pressure of pressure
Sponsors
Chinese PLA General Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Their American Society of Anesthesiologists (ASA) physical status was 1 or 2 * Body mass index (BMI) ranged from 18 to 26 * None of the patients had known diabetes mellitus, hypertension, cardiovascular, pulmonary, endocrinological, neurological diseases, or diseases that influenced intravascular fluid volume or balance * All patients had a preoperative fast for at least 8 h and routine atropine intramuscular injection
Exclusion criteria
* Persistent arrhythmias * Intraoperative application of vasoactive drugs except phenylephrine, dopamine and ephedrine
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| invasive arterial blood pressure as a Measure of Safety | DAY 1 | if instability of circulation, stop the clinical trial |
Outcome results
None listed