Ovarian Hyperstimulation Syndrome
Conditions
Keywords
OHSS, Oocytes triggering, GnRh agonist triggering, Luteal phase supplementation, recombinant LH
Brief summary
The purpose of this study is to prove that luteal phase supplementation with recombinant LH can solve the luteal phase deficiency after Gnrh agonist oocytes triggering in women at risk of OHSS
Detailed description
The investigators enrolled patients, undergoing controlled ovarian stimulation for an IVF/ICSI cycles, who on the day of oocytes triggering were at risk of OHSS. These patients had an estradiol \> 4000 pg/ml and more than 24 follicles with a diameter greater than 12 mm. The investigators used 0,2 mg of triptorelin for the oocytes triggering and supplemented the luteal phase with recombinant LH at a dose of 75 UI twice/day for 10 days and vaginal gel progesterone and oral oestradiol for 14 days The investigators measured bhCG at 14 days from the pick up. In case of positive bhCG we have defined the IVF/ICSI outcome: Pregnancy Rate and Implantation Rate.
Interventions
DRUGrecombinant LH
recombinant LH twice/day for 10 days from pick up
Sponsors
San Carlo Public Hospital, Potenza, Italy
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 43 Years
Healthy volunteers
No
Inclusion criteria
* patients with an oestradiol \> 4000 pg/ml on the oocytes triggering day * patient with more than 24 follicles of diameter greater than 12 mm on the oocytes triggering day
Exclusion criteria
* patients with no risk of OHSS on the oocytes triggering day * patients with an oestradiol \< 4000 pg/ml on the oocytes triggering day * patient with less than 24 follicles of diameter greater than 12 mm on the oocytes triggering day
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pregnancy Rate and Implantation Rate | From 14 days after the pick up to six weeks of gestation | We measured bhCG after 14 days from the pick up. In presence of a positive value of bhCG we evaluated IVF/ICSI outcome through the pregnancy rate and implantation rate. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Ealy and Late Ovarian Hyperstimulation Syndrome | From 9 days after pick up to 12 weeks of gestation | We evaluated early and late ovarian hyperstimulation syndrome according the practice committee of ASRM 2008 and Current Clinical Guideline for OHSS of 2010 |
Countries
Italy
Outcome results
None listed