Effect of General Anesthesia on Enterocyte Damage

Impact of General Anesthesia on Enterocyte Damage

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02199275

Acronym

GUT

Enrollment

Registered

2014-07-24

Start date

2013-08-31

Completion date

2014-08-31

Last updated

2014-07-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

General Anesthesia, Non-urgent Surgery

Keywords

Non-urgent surgery, General anesthesia, Enterocyte damage, Intestinal fatty acid-binding protein

Brief summary

During non urgent surgery, general anesthesia might induce enterocyte damage. I-FABP is a performant biomarker of enterocyte damage. We aimed to study whether patient ongoing general anesthesia for non-urgent surgery have an elevation of plasma I-FABP concentration.

Detailed description

Inclusion criteria * Indication of non-urgent surgery * General anesthesia protocol using propofol and remifentanyl * One half of the patients have a history of ischemic arteriopathy * One half of the patients have no history of ischemic arteriopathy Exclusion criteria * Age \< 18 years old * Pregnant Primary objective Is there a significant elevation of I-FABP between the pre-anesthesic period and 11 minutes after induction of general anesthesia ? Secondary objectives 1. Is I-FABP elevation higher among patients with history of patent arteriopathy ? 2. Is I-FABP elevation higher among patients presenting with hypotension during anesthesia ?

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Indication of non-urgent surgery * General anesthesia protocol using propofol and remifentanyl * One half of the patients have a history of ischemic arteriopathy * One half of the patients have no history of ischemic arteriopathy

Exclusion criteria

* Age \< 18 years old * Pregnant

Design outcomes

Primary

Measure	Time frame	Description
I-FABP elevation after induction of general anesthesia	11 minutes	Primary measure of plasma I-FABP before induction of general anesthesia. Second measure of plasma I-FABP concentration 11 minutes after induction of general anesthesia using a protocol of propofol and remifentanyl with monitoring of bispectral index.

Countries

France

Outcome results