Barrett Esophagus, GERD - PPI Non-responders, GERD - PPI Responders, Healthy Volunteers
Conditions
Keywords
acid pocket, GERD, Barrett
Brief summary
Gastroesophageal reflux disease (GERD) is a very common condition affecting up to 30% of adults. To date, therapy consists of powerful acid suppression with proton pump inhibitors (PPI). Nevertheless, only 60-70% of GERD patients report complete symptom relief with this therapy. As the mechanisms underlying symptom perception in PPI resistant patients are not fully understood, there is currently no adequate therapy available. It is becoming increasingly clear that reflux, especially in the postprandial period, occurs from a reservoir of acid floating on top of the meal: the so-called acid pocket. In this study, we aim to investigate further the acid pocket by determining its exact position and chemical contents between healthy volunteers, GERD patient who respond well and bad to PPI therapy and GERD patients with barrett's esophagus.
Detailed description
A costume made multi-pH-impedance manometry catheter will be placed in the esophagus and clipped to the Z-line. Patients then will be given a standardized meal and the position of the acid pocket will be measured. After two hours the pocket will be aspirated through a gastric catheter. Then, patients will be allowed to return home and the study will be continued for another 22 hours. The special catheter will be removed at the end of the study. Collected acid pockets will be used to analyze content and perform permeability experiments. Data of the 24-hour experiment will be used to evaluate the position of the acid pocket and number of reflux episodes.
Interventions
DEVICEmulti-pH-impedance manometry catheter
a special catheter will be placed in the esophagus of all study groups. Measurment of pH, impedance and pressure will be performed.
Sponsors
KU Leuven
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* signed informed consent * older than 18 years * fit to criteria of 'study population' (HV, PPI responder, PPI non-responder, Barrett)
Exclusion criteria
* pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| acid pocket position | participants will be followed for 24 hours | Acid position will be determined relatively to the lower esophageal sfincter. Differences in position between healthy volunteers, PPI responders, PPI non-responders and patients with barrett esophagus will be evaluated |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| number of reflux episodes | 24 hours | number of reflux episodes will be counted and compared between the different groups. |
Other
| Measure | Time frame | Description |
|---|---|---|
| acid pocket contents | 1 year | after collection of all acid pocket, pockets will be processed to determine it's exact chemical content. |
Countries
Belgium
Outcome results
None listed