Alzheimer's Disease
Conditions
Keywords
Alzheimer's, MRI, APOE
Brief summary
The purpose of this study is to investigate the influence of the APOE genotype on brain morphology, function and metabolism, related to other factors such as cognitive reserve, cognition and episodic memory, in subjects at greater risk of developing AD.
Detailed description
The purpose of this study is to investigate the influence of age and the APOE genotype on brain morphology and function, in 700 cognitively healthy individuals, 45 to 75 years old, recruited from an ongoing longitudinal cognition study exploring memory and executive functions (ClinicalTrials.gov ID: NCT01835717). All subjects have been APOE genotyped and underwent a clinical and cognitive assessment. Within this study, the subjects will be submitted to an MRI scanning protocol including morphological and resting state acquisitions. An identical follow-up MRI session will be performed in 2 years' time. The analyses will be focused on detecting the effect of the APOE allelic variants on the change rate of the neuroimaging variables as well as its interaction with aging.
Interventions
None listed
Sponsors
Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
45 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Participant included in the study ClinicalTrials.gov ID: NCT01835717 * APOE genotype obtained before MRI acquisition * Be willing to perform an MRI and agree to a 2 years longitudinal follow up * Sign informed consent
Exclusion criteria
* Contraindication to MRI scanning: claustrophobia, pacemaker, history of ocular cerclage, heart valves, aneurysm clips and carrying any metal prosthesis incompatible with MRI. * Incidental MRI findings that result in the images not being included in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hippocampal atrophy | 2 years |
Countries
Spain
Outcome results
None listed