Research of the Application of Triple Antibiotic Paste in Primary Teeth With Pericpical Periodontitis

Randomized Controlled Research of the Application of Triple Antibiotic Paste in Primary Teeth With

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02196740

Enrollment

100

Registered

2014-07-22

Start date

2013-06-30

Completion date

2015-06-30

Last updated

2014-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periapical Diseases

Keywords

periapical periodontitis,primary teeth

Brief summary

The triple antibiotic paste is widely used in young permanent teeth and permanent teeth root canal therapy with excellent antiantimicrobial effect.We hypothesize that its application in the treatment of periapical periodontitis of deciduous teeth is superior to other drugs currently in use as creosote.

Detailed description

We design to collect a group of patients presenting primary teeth with periapical periodontitis in certain criterion. We will divide the patients into two groups randomly.One group will get treated with triple antibiotic paste while the other with creosote.We want to evaluate the short-term and long-term effects of the two groups to get a conclusion of the clinical value of triple antibiotic paste.

Interventions

DRUGMetronidazole-Ciprofloxacin gatifloxacin-Clindamycin paste

Pulp removal,Root canal irrigation and disinfection,

DRUGcreosote

Pulp removal,Root canal irrigation and disinfection

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

3 Years to 8 Years

Healthy volunteers

Inclusion criteria

* clinical diagnosis of periapical periodontitis * must be primary teeth * must be 3\ 8 years old * the permanent tooth germ is complete and didnot be involved

Exclusion criteria

* blood disease * residual root that is advised to extract * serious periodontitis * allergy to the triple antibiotic paste

Design outcomes

Primary

Measure	Time frame
Evidence of lesion healing confirmed by cone beam computed tomography and X-rays	1 year

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026