Female Infertility Due to Diminished Ovarian Reserve
Conditions
Keywords
Growth hormone, IVF/ICSI, Poor responder, Antagonist protocol
Brief summary
The effect of use of the growth hormone with antagonist protocol on the outcome of the IVF/ICSI cycles in poor responders.
Detailed description
Two groups of poor responder female patients planned to receive the antagonist IVF/ICSI protocol are randomized to whether or not to add growth hormone to their protocol.
Interventions
DRUGGrowth Hormone
Growth hormone (Norditropin, Novo nordisk) was administrated on day 6 of HMG stimulation daily in a dose of 2.5 mg S.C. till the day of hCG administration.
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* females fulfilling the criteria of the ESHRE consensus 2011: * at least two of the following three features must be present: * dvanced maternal age (≥40 years) or any other risk factor for POR * previous POR (≤3 oocytes with a conventional stimulation protocol) * an abnormal ovarian reserve test (i.e. AFC ,5-7 follicles or AMH ,0.5 -1.1 ng/ml).
Exclusion criteria
* women who suffer from any other cause of infertility other than poor ovarian reserve * refusal of the patient to consent for using her data in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth rate | Up to 9 months |
Secondary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate | Up to 5 weeks |
Other
| Measure | Time frame |
|---|---|
| Chemical pregnancy rate | 5 weeks |
| Early miscarriage rate | Up to 12 weeks |
| Ongoing pregnancy rate | Up to 12 weeks |
Countries
Egypt
Outcome results
None listed