Inferior Vena Cava Collapsibility Index in Severe Sepsis

Bedside Ultrasound of Inferior Vena Cava Collapsibility in Emergency Department Patients Presenting With Severe Sepsis and Septic Shock

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02195830

Enrollment

112

Registered

2014-07-21

Start date

2014-07-31

Completion date

2015-07-31

Last updated

2014-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis, Septic Shock, Severe Sepsis

Keywords

Sepsis, ultrasound, inferior vena cava collapsibility

Brief summary

There is debate regarding the use of non invasive (ultrasound assessed) parameters of fluid volume status in patients with sepsis. To establish the role of inferior vena cava ultrasound in guiding fluid resuscitation we first need to define the inferior vena cava collapsibility index in this population of patients. The research question is: In adult patients with sepsis, severe sepsis and septic shock what is the mean baseline inferior vena cava collapsibility index (IVCCI) prior to fluid resuscitation.

Detailed description

The study is an interventional cohort study using a convenience sample of adult patients in a university teaching hospital Emergency Department. Eligible participants who consent to partake in the trial will have an ultrasound assessment of their inferior vena cava performed and the IVCCI will be calculated at enrolment. Care will be provided in line with the published guidelines on sepsis management from the Surviving Sepsis Campaign and the College of Emergency Medicine. A sample size calculation has been performed which indicates that 112 patient with severe sepsis or septic shock will need to be enrolled.

Interventions

OTHERUltrasound of the inferior vena cava

B mode ultrasound of the inferior vena cava Measurements taken 2cm from the hepatic vein IVC junction or 3cm from the right atrium IVC junction

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adult patients * signs and symptoms of infection with 2 or more SIRS criteria (pulse rate \>90/min, Temp \> 38 Celsius \< 36 Celsius, Respiratory rate \> 20 breaths per minute, or white cell count \>12 or \<4 x 10\^9/L)

Exclusion criteria

* in relation to this episode of care: Prior cardio pulmonary resuscitation, acute myocardial infarction, trauma, pregnancy or patient requiring immediate surgery. * Patients who have received more than 20ml/Kg of IV fluid in the pre hospital environment * Patients with known tricuspid regurgitation, congestive heart failure or pulmonary hypertension * Patients receiving palliative terminal supportive care

Design outcomes

Primary

Measure	Time frame
Mean baseline inferior vena cava collapsibility index	At enrollment

Countries

United Kingdom

Contacts

Primary ContactSimon Richards, MHSc

s.richards@tees.ac.uk

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026