Efficacy of RIPC to Reduce AKI for Patients Undergoing PCI

Conditions

Acute Kidney Injury

Brief summary

The purpose of the present study is to determine if remote ischemic preconditioning reduces incidence of acute kidney injury in patients with reduced kidney function undergoing Percutaneous Coronary Intervention.

Detailed description

Acute kidney injury negatively impacts on prognosis after PCI, and only hydratation have shown to reduce this complication. Remote ischemic preconditioning has been demonstrated to reduce periprocedural MI, while impact on aki remains to be assessed

Saveria Femminò, Fabrizio D’Ascenzo, Francesco Ravera, Stefano Comità, Filippo Angelini et al. (16 authors)

International Journal of Molecular Sciences2021-09-2422 citations

10.3390/ijms221910270

Extracellular vesicles from patients with Acute Coronary Syndrome impact on ischemia-reperfusion injury.

D'Ascenzo F, Femminò S, Ravera F, Angelini F, Caccioppo A, Franchin L, Grosso A, Comità S, Cavallari C, Penna C, De Ferrari GM, Camussi G, Pagliaro P, Brizzi MF.

2021-06-0727 citations

10.1016/j.phrs.2021.105715

The EUROpean and Chinese cardiac and renal Remote Ischemic Preconditioning Study (EURO-CRIPS CardioGroup I): A randomized controlled trial.

Moretti C, Cerrato E, Cavallero E, Lin S, Rossi ML, Picchi A, Sanguineti F, Ugo F, Palazzuoli A, Bertaina M, Presbitero P, Shao-Liang C, Pozzi R, Giammaria M, Limbruno U, Lefèvre T, Gasparetto V, Garbo R, Omedè P, Sheiban I, Escaned J, Biondi-Zoccai G, Gaita F, Perl L, D'Ascenzo F.

2018-04-0145 citations

10.1016/j.ijcard.2017.12.033

Interventions

PROCEDURERemote ischemic preconditioning

four times 5-minute inflations of a blood pressure cuff to 200 mmHg around the upper non dominant arm (or if systolic pressure is more than 150 mmHg, inflation will reach 50 mmHg up per than baseline), followed by 5-minute intervals of reperfusion.

PROCEDURESham remote ischemic preconditioning

In the control group sham preconditioning will be performed with inflation of 10 mmHg more than baseline.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

No

Inclusion criteria

* undergoing PCI with stenting for all clinical indications * carrying (with) a renal clearance less than 60 mL/min/1.73 m2 and more than 30 mL/min/1.73 m2 (evaluated through MDRD); ù * younger than 85 years old.

Exclusion criteria

* ST Segment Elevation Myocardial Infarction (STEMI), unstable hemodynamic presentations (cardiogenic shock) or ongoing severe arrhythmias;

Design outcomes

Primary

Measure	Time frame	Description
Incidence of acute kidney injury	24 and 48 hours after PCI	Acute Kidney Injury defined as Acute kidney injury is defined as an increase serum creatinine greater than 0.5 mg/dL, or by a relative increase of at least 25% over the baseline value within a period of 48-hours after contrast medium administration

Secondary

Measure	Time frame
Incidence of periprocedural myocardial infarction	24 and 48 hours after PCI

Countries

France, Italy, Spain

Outcome results

None listed