Hypomotility, Constipation
Conditions
Keywords
constipation, colon transit time, gut microbiota, soluble dietary fiber, disturbance of gut microbiota in constipation
Brief summary
The purpose of this study is to investigate the effect of pectin, a kind of soluble dietary fiber, on colonic transit time, clinical symptoms and the gut microbiota in adults with slow-transit constipation.
Detailed description
Patients were randomized to receive either pectin or placebo. Treatment consisted of 4 weeks supplementation with pectin (fiber group) or placebo. We evaluated the colonic transit time, constipation symptoms and fecal bacterial population in two groups.
Interventions
DRUGPectin
pectin （Andeli Ltd. Yantai, China）, 24g/d for 4weeks
Sponsors
Nanjing PLA General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 78 Years
Healthy volunteers
No
Inclusion criteria
* All patients(age≧18y) * Admitted for slow-transit constipation were considered eligible
Exclusion criteria
* Mental disorders * Cancer * Inflammatory bowel disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| efficacy: intestinal transit time | four weeks after inclusion | colonic transit time |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| efficacy: clinical symptoms | four weeks after inclusion | Wexner constipation score |
| efficacy: gut microbiota | four weeks after inclusion | real-time PCR |
Outcome results
None listed