C.Delivery; Surgery (Previous), Gynecological
Conditions
Keywords
rocuronium, cisatracurium, pharmacokinetic
Brief summary
The investigators investigated whether laparoscopic versus open surgical approaches affected the pharmacokinetic and pharmacodynamic of a single bolus dose of rocuronium or cisatracurium.
Interventions
DRUGrocuronium
Rocuronium 0.6 mg.kg-1 was administered within 5 s as an intravenous bolus
DRUGcisatracurium
cisatracurium 0.15mg.kg-1 was administered within 5 s as an intravenous bolus
Sponsors
Fudan University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiology 1-2 * BMI 18-30 kg.m-2 * elective gynaecological operations under general anaesthesia
Exclusion criteria
* cirrhosis * hepatitis * hepatoma * heart failure * arrhythmia * renal dysfunction * electrolyte disturbances * acid-base imbalances * neuromuscular disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the blood flow in the right and middle hepatic veins | up to 9 months | Measurements of the blood flow in the right and middle hepatic veins were performed at baseline and 1,5, 10, 20, 30min after insufflation of carbon dioxide or incise the skin as well as 1 and 5 min after deflation or close the wound. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the plasma Concentration of rocuronium and cisatracurium | up to 9 months | Venous blood samples (3 ml) were taken 2 min prior to and at 5,30, 60 min following administration of rocuronium/cisatracurium.The aim of the present was to study the blood concentration of rocuronium/cisatracurium in laparoscopic surgery compared with conventional open gynaecological surgery |
Other
| Measure | Time frame | Description |
|---|---|---|
| pharmacodynamic comparison of rocuronium and cisatracurium | up to 9 months | This study was undertaken to investigate the duration of action of 0.9 mg.kg-1 rocuronium or cisatracurium 0.15 mg.kg-1 administered during laparoscopic surgery compared with conventional open gynaecological surgery.Adductor pollicis train-of-four responses following ulnar nerve stimulation were monitored with mechanomyography.We recorded the time from the end of injection of rocuronium or cisatracurium to time to recovery of T1, and to recovery to 5% and 25% of baseline height |
Outcome results
None listed