Healthy
Conditions
Brief summary
Interesterified (IE) fat blends will respond differently in terms of postprandial lipemia and insulinemic responses compare to a trans free palm margarine (TFPM).
Detailed description
The objective of this study was to investigate whether IE-fat blends behave differently on postprandial serum lipid, insulin, C-peptide and glucose concentration compare to TFPM. A randomised, double-blind crossover (3 × 3 arms) orthogonal Latin-square design was used and conducted on 10 males and 10 females adults. During postprandial challenge day, each subject received an a test muffin incorporated with test margarine. Blood samples were collected at half-hourly intervals until 4 hr by using cannulation technique.
Interventions
OTHERTrans free palm margarine
A randomised, double-blind crossover (3 × 3 arms) orthogonal Latin-square design was used and conducted on 10 males and 10 females adults.
OTHERInteresterified Palm based margarine
A randomised, double-blind crossover (3 × 3 arms) orthogonal Latin-square design was used and conducted on 10 males and 10 females adults.
OTHERIE Soybean oil-based margarine
A randomised, double-blind crossover (3 × 3 arms) orthogonal Latin-square design was used and conducted on 10 males and 10 females adults.
Sponsors
IMU University, Malaysia
Universiti Putra Malaysia
Malaysia Palm Oil Board
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Body Mass Index (BMI) between 18.5 and 24.9 * \<130mmHg for systolic pressure and \<80 mmHg for diastolic pressure * Blood glucose level in the range of 3.9 to 5.5 mmol/L * Total cholesterol less than 5.17 mmol/L * No use of tobacco and no consumption of alcohol.
Exclusion criteria
* Suffer from chronic disease * Metabolic syndrome * Consuming any medical prescriptions * People with blood clotting problem * Women who are pregnant * Hypertensive person
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in serum triglycerides level of subjects as a measure of postprandial triglycerides response | Baseline, 4 hours |
Secondary
| Measure | Time frame |
|---|---|
| Change in the level of plasma insulin, c-peptide and serum glucose as a measure of postprandial insulinemic response | Baseline, 4 hours |
Countries
Malaysia
Outcome results
None listed