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Endoscopic Size Assessment of Advanced Adenomatous Polyps

Endoscopic Size Assessment of Advanced Adenomatous Polyps; Inter Observer Variations

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT02193646
Enrollment
1930
Registered
2014-07-17
Start date
2010-11-30
Completion date
2025-01-31
Last updated
2025-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adenoma Detection Rate Improvement in Screening Colonoscopy

Keywords

Colonoscopy, Adenoma, ADR, Screening Colon Cancer

Brief summary

The investigators are retrospectively comparing detection rates of adenomatous polyps, advanced adenomas, and size assessment of the polyps among Rush University Medical Center endoscopists. The investigators plan to review whether the size assessment of adenomatous polyps affected the surveillance protocols and if the location of polyps detected affected the detection rates.

Detailed description

The study plans to compare detection rates of adenomatous as well as the sessile serrated polyps, advanced adenomas and size assessment of the polyps among the endoscopists at the study site. In addition, the study team aims to evaluate rates of advanced neoplasia on surveillance colonoscopy based on certain features on initial colonoscopy and patient characteristics, including specific high-risk histologic features and concurrent medication usage such as aspirin. In addition, patients with at least one adenoma on surveillance colonoscopy will be identified and regarded as cases. Cases will be compared against normal surveillance colonoscopy. The Controls will be selected on a 1:1 ratio. Aspirin use will be compared between groups.

Interventions

None listed

Sponsors

Rush University Medical Center
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
40 Years to 80 Years
Healthy volunteers
Yes

Inclusion criteria

* Presence of adenomatous polyps detected at endoscopy and diagnosed pathologically by tissue biopsy * Have a colonoscopy at RUMC for screening purposes

Exclusion criteria

* Failure to meet inclusion criteria * Previous diagnosis of IBD or colorectal cancer

Design outcomes

Primary

MeasureTime frameDescription
Adenomatous Polyp Detection Rateone yearAssessing for advanced adenomas (including location).
Endoscopic Size Assessment Versus Pathological Size Assessmentone yearSize of polyps at time of endoscopic procedure will be compared to the size of the same polyp by pathological assessment.

Secondary

MeasureTime frameDescription
Retroflexion as an indication of adenoma detection rate in colorectal cancer screeningone yearRetroflexion is a common but not mandatory practice in colonoscopy which as not been systematically studied in terms of polyp detection. Charts will be reviewed to determine whether retroflexion was performed.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026