Systemic Inflammatory Response Syndrome, Inflammation
Conditions
Brief summary
The purpose of this study is to access the effect of Transcutaneous Electrical Acupoint Stimulation(TEAS) on the Incidence rate of Systemic Inflammatory Response Syndrome (SIRS) in patients undergoing radical surgery for gastric cancer
Detailed description
Patients undergoing elective radical surgery for gastric cancer under general anesthesia were randomly assigned to three groups, control group , TEAS group and sham TEAS group. TEAS group receiving TEAS before general anesthesia induction , 1th day and 2nd day after surgery. TEAS was given through electrodes attached to specific acupoints. The time for TEAS was 30min. Sham TEAS group receiving sham TEAS before general anesthesia induction , 1th day and 2nd day after surgery. Sham TEAS was given through electrodes attached to non-acupoints. The time for sham TEAS was also 30min. Control group were given no TEAS. Incidence rates of SIRS in each group were compared .Venous blood samples from all groups(control group , TEAS group and sham TEAS group) were collected before general anesthesia induction,1th day and 3rd day after surgery. Inflammatory cytokines index including interleukin-6,interleukin-10,Tumor Necrosis Factor- alpha(TNF-α),Interferon-γ(IFN-γ),Monocyte Chemotactic Protein 1(MCP-1),IgG,IgM were measured.
Interventions
DEVICETEAS
Electric stimulation was given through electrode attached to specific acupoints for 30mins before general anesthesia induction,1th day and 2nd day after surgery.
DEVICESham TEAS
Electric stimulation was given through electrode attached to non-acupoints for 30mins before general anesthesia induction,1th day and 2nd day after surgery.
Sponsors
Air Force Military Medical University, China
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
30 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Age\>30yrs,\<75yrs * ASA 1-2 * Scheduled for radical surgery for gastric cancer under general anesthesia； * Informed consented
Exclusion criteria
* Patients with implanted pacemakers * Patients with severe hypertension or cardiac dysfunction； * Patients with severe pulmonary disease * Patients with hemoglobin\<90g/L
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence rate of SIRS | 1st day after surgery | SIRS is defined as 2 or more of the following variables : 1. Fever of more than 38°C (100.4°F) or less than 36°C (96.8°F) 2. Heart rate of more than 90 beats per minute 3. Respiratory rate of more than 20 breaths per minute or arterial carbon dioxide tension (PaCO2) of less than 32mm Hg 4. Abnormal white blood cell count (\>12,000/µL or \< 4,000/µL or \>10% immature granulocyte forms) Incidence rate of SIRS is calculated using the following formula: (Number of SIRS Cases within the group) / (Number of Cases within the group) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of Inflammatory cytokines | 30 minutes before general anesthesia induction and 1st and 3rd day after the surgery | Venous blood samples were collected before general anesthesia induction,1th day and 3rd day after surgery. Inflammatory cytokines index including interleukin-6,interleukin-10,TNF-α,Interferon-γ(IFN-γ),Monocyte Chemotactic Protein 1(MCP-1),IgG,IgM were measured. |
| Incidence rate of SIRS | 3rd day after surgery | SIRS is defined as 2 or more of the following variables : Fever of more than 38°C (100.4°F) or less than 36°C (96.8°F) Heart rate of more than 90 beats per minute Respiratory rate of more than 20 breaths per minute or arterial carbon dioxide tension (PaCO2) of less than 32mm Hg Abnormal white blood cell count (\>12,000/µL or \< 4,000/µL or \>10% immature granulocyte forms) Incidence rate of SIRS is calculated using the following formula: (Number of SIRS Cases within the group) / (Number of Cases within the group) |
Countries
China
Outcome results
None listed