Metabolic Syndrome and Contrast Induced Nephropathy

Impact of Metabolic Syndrome on Development of Contrast Induced Nephropathy After Elective Percutaneous Coronary Intervention

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02192372

Enrollment

599

Registered

2014-07-16

Start date

2014-02-28

Completion date

2014-07-31

Last updated

2014-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Contrast Induced Nephropathy, Metabolic Syndrome

Keywords

creatinine, glomerular filtration rate, metabolic syndrome

Brief summary

Prevention of contrast induced nephropathy after interventional cardiologic procedures deserves close interest because of its association with prolonged hospitalization, increased cost and increased in hospital and long term mortality rates. An observational prospective cohort study was designed to determine whether metabolic syndrome predicts the development of contrast induced nephropathy after elective percutaneous coronary intervention.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

Patients must be scheduled for elective percutaneous coronary intervention Clinical diagnosis of metabolic syndrome Patients must give informed consent

Exclusion criteria

Acute coronary events Acute renal failure End stage renal failure requiring hemodialysis Contrast allergy and exposure to nephrotoxic agent within 1 week before percutaneous coronary intervention Exposure to contrast agent within 1 week before the procedure.

Design outcomes

Primary

Measure	Time frame	Description
Contrast induced nephropathy	24-48 hours after the percutaneous coronary intervention	Contrast induced nephropathy was defined as an increase in serum creatinine of \>25% or \>0.5 mg/dl above the baseline value 24 or 48 hours after angiography.

Secondary

Measure	Time frame	Description
glomerular filtration rate	48 hours after the percutaneous coronary intervention	Glomerular filtration rate was estimated using the Cockcroft-Gault formula: (140-age) x weight (kg)/ serum creatinine (mg/dl) x 72 (x 0.85 for females)

Other

Measure	Time frame
Cut-off point for baseline glomerular filtration rate to predict development of contrast induced nephropathy	baseline glomerular filtration rate

Countries

Turkey (Türkiye)

Outcome results