Investigating a Model for Acute Ischemic Pain in Humans

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02192242

Enrollment

Registered

2014-07-16

Start date

2007-06-30

Completion date

2008-08-31

Last updated

2014-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peripheral Arterial Disease

Keywords

acute ischemic pain, model, S100, interleukine 6

Brief summary

The pathophysiology of acute ischemic pain is not well established. The aim of the present study was to investigate acute ischemic pain in humans with a view to establish a scientific model to perform future studies. The investigators examined whether peripheral nerve damage and acute inflammation occur during short episodes of acute ischemia.

Interventions

OTHERacute ischemic pain

acute ischemic pain was induced by treadmill exercise

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

40 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients over 40 years * unilateral femoral-popliteal PAD, Fontaine grade II

Exclusion criteria

* patients with pain at rest or other pain origin * diabetic polyneuropathy * deep vein thrombosis

Design outcomes

Primary

Measure	Time frame	Description
Induce acute ischemic pain	during treadmill exercise (less than 15 minutes)	To induce acute ischemic pain, patients performed treadmill exercise until intolerable pain developed.

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026