Overweight
Conditions
Brief summary
The investigators hypothesized that there will be a significant difference between the effects of trans-free palm-, interesterified palm- and interesterified soybean oil blend on cardiovascular disease, inflammation, insulin resistance and obesity.
Detailed description
Human volunteers will be conditioned for a 8 wk intervention on 3 different test diets providing 30 % energy as fat, 15% energy as protein and 55% energy as carbohydrate according to parallel designed sequences. The test fats used for this study are palm oil, chemically interesterified palm oil and chemically interesterified fully hydrogenated soybean oil and soft oil blend in the form of margarine. Volunteers will be restricted to follow the dietary guidelines throughout the study. Blood collection sessions will held before and after every diet intervention. Outcome measures of the study are serum lipid profile, markers of inflammation, markers of obesity and insulin resistance.
Interventions
Sponsors
IMU University, Malaysia
Universiti Putra Malaysia
Malaysia Palm Oil Board
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Adult males and females, aged 20-60 yr * Staff and students of International Medical University, IMU/ Staff of Malaysian Palm Oil Board, MPOB to facilitate centralized consumption of the test fats/snacks * BMI 21 - 30 kg/m2
Exclusion criteria
* Abnomal liver function test (elevated transaminases- alanine aminotransferase,ALT; aspartate aminotransferase,AST))/ abnormal kidney function test (elevated plasma creatinine) * History of type 2 diabetes mellitus, cancer, stomach ulcers, drug abuse or alcoholism * Smokers * On lipid/blood pressure- lowering medication/supplements * Blood pressure\>140/90 mmHg * Fasting total cholesterol \> 6.5 mmol/L * Fasting TAG \> 2.0 mmol/L * Candidates who are going abroad during the planned schedule for the dietary intervention
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in serum C-peptide level of subject | up to 8 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Change in serum lipid profile | up to 8 weeks |
| Change in markers of inflammation | up to 8 weeks |
| Change in markers of obesity | up to 8 weeks |
| Change in markers of insulin resistance | up to 8 weeks |
| Oral Glucose tolerance test (OGTT) | Baseline, month-2 |
Countries
Malaysia
Outcome results
None listed