Anemia During Pregnancy, HIV, Syphilis
Conditions
Keywords
PMTCT, HIV, Syphilis, Anemia during pregnancy, Point of care diagnostics
Brief summary
The general goal of the proposed study is to evaluate the cost-effectiveness of POC technologies for diagnosis of syphilis, quantitative analysis for hemoglobin and CD4 counting performed within MCH services to improve maternal and infant health. A prospective, quasi-experimental study will be done in Cabo Delgado province, where health facilities will be randomized in an intervention or comparison arm. Outcomes on maternal and infant health will be measured.
Interventions
DEVICEPIMA® for quantitative analysis of CD4-count
DEVICEHemocue® (HemoCue AB, Angelhom, Sweden) for quantitative analysis of hemoglobin
DEVICESD Bioline® (Standard Diagnostics Inc., South-Korea) for qualitative analysis of syphilis
Sponsors
Ministry of Health, Mozambique
Elizabeth Glaser Pediatric AIDS Foundation
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
Before and after intervention study design
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* First antenatal care visit * Able to provide informed consent and signed consent form * Minimum 18 years of age * Diagnosed HIV positive at antenatal care visit * Living in the catchment area of the health facility
Exclusion criteria
* Age \<18 years * No consent form signed * Being on ART at time of first antenatal care visit
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The proportion of HIV positive pregnant women initiating antiretroviral therapy among eligible women. | Within 1 month | Number of HIV positive pregnant women initiating antiretroviral therapy divided by the number of eligible HIV positive pregnant women |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of women at first ANC visit tested and treated for syphilis | Within 1 month | Number of women at first ANC tested and treated for syphilis divided by the number of women attending first ANC visit |
| The proportion of pregnant women tested and treated for anemia | Within 1 month | Number of pregnant women test and treated for anemia divided by the number of pregnant women |
| Number of HIV infections in infants averted | 1-3 months of age | Number of HIV-positive pregnant women who accessed antiretrovial therapy in a timely manner |
Outcome results
None listed