Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System

Effect of Surgical Periodontal Therapy on the RANKL/OPG System : Do we Need Osteo-immune Modulation Targeting RANKL?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02190773

Enrollment

Registered

2014-07-15

Start date

2010-01-31

Completion date

2013-04-30

Last updated

2014-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aggressive Periodontitis, Chronic Periodontitis, Gingival Crevicular Fluid, RANKL/OPG Ratio

Keywords

Chronic Periodontitis, Aggressive Periodontitis, RANKL/OPG ratio, Gingival crevicular fluid

Brief summary

In the present clinical study including chronic, aggressive periodontitis and healthy individuals, the investigators aimed to determine the RANKL, osteoprotegrin (OPG), Interleukin-1 (IL-1β), IL-10, IL-1β levels in gingival crevicular fluid(GCF) before and after surgical periodontal treatment and search out the relationship of clinical parameters with these cytokine levels.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Chronic periodontitis having at least 5mm or more probing depth and aggressive periodontitis patients.

Exclusion criteria

* Any known systemic disorder, used antibiotics and/or anti-inflammatory medications, had periodontal treatment in the last 3 months and all of them were non smokers. Subjects who were lactating and pregnant were also excluded.

Design outcomes

Primary

Measure	Time frame	Description
RANKL (pmol) level in GCF	Baseline-3 months	Changes in RANKL levels 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis determined by ELISA
OPG level (pg) in GCF	Baseline-3 months	Changes in OPG levels 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis determined by ELISA
RANKL/OPG ratio	Baseline - 3months	RANKL/OPG ratio changes 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis

Secondary

Measure	Time frame	Description
IL-1β (pg) levels in GCF	Baseline, 3 months after treatment	Changes in IL-1β levels (determined by ELISA) 3 months after surgical periodontal treatment in Chronic and Aggressive Periodontitis groups
Il-10 (pg) levels in GCF	Baseline-3 months	Changes in IL-10 levels (determined by ELISA) 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis

Countries

Turkey (Türkiye)

Outcome results