Genetic Susceptibility, Graves Disease, Hashimoto's Thyroiditis, Hyperthyroidism, Hypothyroidism, Iodine Deficiency, Subclinical Hyperthyroidism, Subclinical Hypothyroidism
Conditions
Keywords
Hyperthyroidism, Hypothyroidism, Autoimmune thyroid disorders, Iodine deficiency, Genetic susceptibility
Brief summary
This will be a population based study looking at the prevalence of thyroid disorders in Malaysia (including hypo- and hyperthyroidism, subclinical hypo- or hyperthyroidism) and its association with different ethnicity and iodine status. The study will also look at genetic susceptibility for autoimmune thyroid disorders in the Malaysian population General hypotheses: The prevalence of thyroid disorders in Malaysia is 10% for hypothyroidism and 2% for hyperthyroidism Hypo- and hyperthyroidism is associated with iodine status in our population There are different susceptibility gene for autoimmune thyroid disorder in different ethnicity in our population
Detailed description
This will be a cross-sectional population based study involving Malaysian adults (aged 18 year old and above). Cluster sampling will be used to select respondents that will be representative of the Malaysian population. Selected respondent will be interviewed, anthropometric measurement taken, blood and urine sample taken. Blood will be analyzed for thyroid function (thyroxine, triiodothyronine and thyroid stimulating hormone), autoantibodies (anti-thyroperoxidase and anti-thyroglobulin). Urine will be analyzed for urinary iodine. Those diagnosed with autoimmune thyroid disorders with strong family history of thyroid disorders (multiplex multi-generation family involvement) will have their blood sent for whole exome sequencing and linkage analysis done to identify possible susceptible gene for autoimmune thyroid disorders Respondents detected to have hypo- or hyper- and subclinical hypo- or hyperthyroidism will be referred to their nearest health centre for further evaluation and treatment appropriate for their condition.
Interventions
None listed
Sponsors
Malaysian Endocrine and Metabolic Society
National University of Malaysia
University of Malaya
IMU University, Malaysia
International Islamic University Malaysia
Study design
Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Aged equal or more than 18 years old at the time of sampling * Malaysian citizen
Exclusion criteria
* Respondents who did not give consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with abnormal thyroid function | Day 0 | Overt or subclinical hypothyroidism Overt or subclinical hyperthyroidism |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with positive thyroid autoantibodies | Day 0 | Anti-thyroglobulin Anti-thyroperoxidase |
| Number of participants with Iodine deficiency status | Day 0 | Urinary iodine level |
Other
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with genetic susceptibility to autoimmune thyroid disorders | Day 0 | whole exome sequencing and linkage analysis in families with autoimmune thyroid disorders (multiplex multi-generation involvement) |
Outcome results
None listed