Effect of Normal Aging on Language Processing

Cognitive Mechanisms and Cerebral Substrate of Naming Impairment During Aging. Behavior and Neuroimaging Approaches.

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02189460

Acronym

SEMVIE

Enrollment

Registered

2014-07-14

Start date

2014-07-31

Completion date

2018-07-31

Last updated

2018-10-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognition

Keywords

Cognition

Brief summary

The purpose of this study is to understand the effect of age on language abilities. The investigators aim at investigating the cerebral modifications that take place in normal aging, at the functional an anatomical level.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Age of 30 years and above * Right handed * French native speakers * Affiliation to French social security (Sécurité Sociale) * Medical interview * Consent form signed

Exclusion criteria

* Cerebral or respiratory pathologies * Any MRI contrindication

Design outcomes

Primary

Measure	Time frame	Description
Blood Oxygen Level Dependent functional MRI	There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year.	We use 3 functional tasks using block paradigm: Object naming, Verbal generation and semantic judgment, to elicit BOLD response using fMRI in order to compare functional activation patterns between subjects. We also use hypercapnic challenge to elicit BOLD response in order to obtain Cerebral Vascular Reactivity properties of subjects.
Anatomical MRI	There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year.	We use Voxel Based Morphometry to compare cortical volume (grey matter) between subjects. We also use tractography Diffusion Tensor Imaging to compare white matter properties between subjects.

Countries

France

Outcome results