Clinical Study of Pain Reduction by Peri-arthroscopic PRP Application in Knee Degeneration

Effect of Platelet Rich Plasma ( PRP ) Applied During Knee Arthroscopy on Pain, Function and Quality of Life - A RCT With a Follow up of 12 Months

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02189408

Acronym

PRP-Bochum

Enrollment

Registered

2014-07-14

Start date

2010-07-31

Completion date

2012-12-31

Last updated

2014-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cartilage Damage, Knee Osteoarthritis, Meniscal Tear

Keywords

Platelet rich plasma, Autologous conditioned plasma, Outerbridge

Brief summary

The purpose of this study is to investigate reduction of pain, gain of function and improvement of life quality by intraoperative applied platelet- rich- plasma ( PRP ) during knee arthroscopy for degeneration and osteoarthritis OA by conducting a randomized- controlled, double-blinded trial ( RCT ) including 58 patients with a follow up of 12 months and pain, assessed by Visual- Analogue Scale (VAS) after 6 months as primary endpoint.

Interventions

BIOLOGICALPlatelet rich plasma

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* degenerative knee pain * age: \> 18 years * informed consent * none to moderate comorbidity * arthroscopy under general anaesthesia indicated

Exclusion criteria

* trauma of the knee within the last 6 weeks before surgery * circumscribed cartilage lesion with possibility of repair microfracture or autologous chondrocyte transplantation - procedures * contraindications against PRP. application * malignancies * severe comorbidities * age \<18 years * physically or mentally not able to provide informed consent * severe knee instability * corticosteroid injections within the last 6 weeks before surgery

Design outcomes

Primary

Measure	Time frame	Description
pain ( VAS )	6 months	measurement of pain using a 100 mm VAS as platelet- rich-plasma demonstrated temporarily analgetic effects up to 6-9 months after application.

Secondary

Measure	Time frame	Description
pain ( VAS )	6 weeks, 12 months	To investigate the pain development over the follow up period at the beginning and the end of our trial
knee function (Lysholm-score )	6 weeks, 6 months, 12 months	to determine PRP-related gain of function according to time after application
quality of life ( physical und mental summaries of SF-36 German version )	6 weeks, 6 months and 12 months	to identify a possible effect of PRP application on life quality ( physical and mental summaries )

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 17, 2026