Effect of Cumulative Chloride Dose on Development of Acute Kidney Injury in Critically Ill Children

Retrospective Investigation of Chloride Dosing and Its Effect on Acute Kidney Injury

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02188602

Enrollment

Registered

2014-07-11

Start date

2013-07-31

Completion date

2015-06-30

Last updated

2022-08-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury

Brief summary

The investigators would like to investigate the effect of chloride dosing on the development of acute kidney injury in critically ill patients. The investigators hypothesis is that administering intravenous fluids with higher chloride content are more likely to lead to acute kidney injury.

Detailed description

Retrospective chart review from 2008-2012 evaluating chloride dosing and serum chloride levels and their effects on acute kidney injury in the pediatric ICU. Patients will be included for the first seven days of their PICU stay.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Months to 18 Years

Healthy volunteers

Inclusion criteria

* age less than 18 years * PICU admitting diagnosis of sepsis, respiratory failure, or hepatic failure.

Exclusion criteria

* hyponatremia or hypernatremia at PICU admission * preexisting diagnosis of End-stage renal disease or renal transplant * presence of neurologic comorbidities.

Design outcomes

Primary

Measure	Time frame	Description
Acute Kidney Injury	7 days	or sooner if death or discharged

Secondary

Measure	Time frame
PICU length of stay	7 days
Hospital length of stay	7 days
Number of ventilator days	7 days
Mortality	7 days

Countries

United States

Outcome results