Assessing The Effectiveness of a Preoperative High Intensity Interval Training Programme In Older Colorectal Cancer Patients

Effectiveness of Short Term, High Intensity, Interval Exercise Training in Older Colorectal Cancer Patients in Improving Preoperative Fitness

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02188342

Acronym

HITCa

Enrollment

Registered

2014-07-11

Start date

2015-01-31

Completion date

2017-04-30

Last updated

2017-07-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preoperative Care, Colorectal Neoplasms, Aged, Exercise

Brief summary

The primary aim of this study is to determine whether an improvement in aerobic fitness, as judged by an increase in VO2peak, can be achieved within 31 days via HIT programme in a group of older, colorectal cancer patients.

Detailed description

12 high intensity interval training exercise sessions on a static cycle ergometer, over a period of 31 days. Each session lasts 18 minutes. At the beginning and end of the study the following measures will be used to assess change in fitness, body composition and muscle metabolism. DXA scan, USS of thigh, VO2 peak cycling test, short performance battery tests, quality of life questionnaires and muscle biopsy.

Interventions

BEHAVIORALHIT

12 HIT exercise sessions in 31 days on a stationary cycle ergometer

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 88 Years

Healthy volunteers

Inclusion criteria

* Confirmed colorectal cancer * Offered curative treatment by the Royal Derby Hospital NHS Foundation Trust Colorectal Cancer Multidisciplinary Team * Male and female * 18-88 years of age

Exclusion criteria

* Uncontrolled hypertension (BP \> 160/100), * Angina, * Heart failure (class III/IV), * Cardiac arrthymias, * Right to left cardiac shunt, * Recent cardiac event, * Previous stroke/TIA, * Aneurysm (large vessel or intracranial), * Severe respiratory disease including pulmonary hypertension, * COPD/asthma with an FEV1 less than 1.5 l, * Coagulation disorders, * Scarring disorders. * Current neoadjuvant chemo/radiotherapy * Inability to complete the consent process Involvement in invasive research study in previous 3 months.

Design outcomes

Primary

Measure	Time frame	Description
VO2 peak	After 31 days of HIT	Mean difference in VO2 peak following a HIT programme

Secondary

Measure	Time frame	Description
Anaerobic threshold	After 31 days of HIT	Mean difference in anaerobic threshold following a HIT programme
Muscle protein synthesis	After 31 days of HIT	Assessment of D2O evaluated muscle protein synthesis following HIT programme
Body composition	After 31 days of HIT	DXA and USS assessed changes in lean muscle mass and architecture following a HIT programme
Feasibility	After 31 days of HIT	Determination of patient compliance and adherence to HIT programme
Quality of life	After 31 days of HIT	Quality of life and performance questionnaires to measure subjective outcomes (EQ-5D, IPAQ, DASI, WEMWBS)

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026