Impact of Muscle Fat Accumulation on the Genomic Profile of Skeletal Muscle in Older Adults

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02187965

Enrollment

Registered

2014-07-11

Start date

2011-08-31

Completion date

2012-08-31

Last updated

2014-07-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intermuscular Adipose Tissue Quantification

Brief summary

Subjects were asked to come to the Purdue facilities after an overnight fast on 2 different testing days for 2.5 hours each day. On one day the subjects participated in blood pressure and body weight measurements as well as a muscle biopsy from the thigh. On the second day the subjects underwent an MRI and MRS scan of the thigh and calf.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

60 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* 60-80 years old, men and women, normal body weight or obese,

Exclusion criteria

* Certain medical conditions could have placed them at risk

Design outcomes

Primary

Measure	Time frame	Description
MRI	1 day	To determine the within day reproducibility of MRI scans for intermuscular adipose tissue (IMAT) quantification in older men and women.

Secondary

Measure	Time frame	Description
genomic profile	1 day	To examine the influence of IMAT accumulation on the genomic profile of skeletal muscle of normal weight or obese adults.

Countries

United States

Outcome results