Delayed Clamping, Milking, Premature Infant, Umbilical Cord
Conditions
Keywords
Hemodynamics, Premature Infant, Umbilical cord, Milking, Delayed clamping
Brief summary
The purpose of this study is to determine whether the umbilical cord milking in preterm infants born by cesarian section less than 34 weeks is more effective than delayed cord clamping to obtain higher levels of hemoglobin.
Interventions
PROCEDUREUmbilical cord milking
Once the preterm is born keep the baby from the mother's thighs. The obstetrician cord milking three times (2seconds/milking) taking the cord from the base 20cm respect towards the baby. Then clamp de cord.
PROCEDUREDelayed cord clamping
Once the preterm is born the neonatologist keep the baby beside the mother at level of the operating table during 30 seconds without cord clamping. The baby is covered with a polythene bag and put a cap on his head. Then the obstetritian clamp the cord.
Sponsors
Corporacion Parc Tauli
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Preterm infants less than 34 weeks' gestation born by cesarean section
Exclusion criteria
* Inability to obtain informed consent from the mother state * Monochorionic-monoamniotic twin gestation * Placenta abruption * Uterine rupture * Transplacental cesarean * Hydrops fetalis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Haemoglobin | 1 hour and 24 hours at born | g/dl |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Arterial pressure | 2, 6, 12, 24, 36 and 48 hours of life | Mean of systolic and dyastolic arterial pressure in mm Hg |
| Orine volume | 24 and 48 hours of life | Total volume of orine at 24 and 48 hours of life. Total ml. |
| Use of vasopresors drugs | 24 hours of life | To use or not to use the vasopresors drugs during the first 24 hours of life |
| Number of concentrate hematies transfusion | participants will be followed for the duration of hospital stay (from 2 weeks up to 3 months) | Total number of concentrate hematies transfusions during the hospital stay. The stay should vary depending of the gestacional age, from 2 weeks up to 3 months. |
| Apgar Score | 1 and 5 minutes | Basic score to mesure the newborn status. From 0 to 10. |
| Bronchopulmonary dysplasia | participants will be followed for the duration of hospital stay (from 2 weeks up to 3 months) | Presence of Bronchopulmonary dysplasia and the degree, mesured by Spanish classification (M. Sanchez Luna) |
| Total intensive care unit stay | Participants will be followed for the duration of hospital stay (from 2 weeks up to 3 months) | Mesured in days. The stay should vary depending of the gestacional age, from 2 weeks up to 3 months. |
| Hematocrit | 1 hour and 24 hours at born | In percentage |
| Intraventricular hemorrhage | participants will be followed for the duration of hospital stay (from 2 weeks up to 3 months) | Presence of intraventricular hemorrhage mesured by cerebral ultrasound Degree of the hemorrhage by Papile |
Countries
Spain
Outcome results
None listed