Plasma Cortisol
Conditions
Brief summary
It has been shown that 5-HTP stimulates cortisol levels in plasma and saliva. Similarly, it has been shown that intense exercise stimulates an increase in plasma and salivary cortisol levels. The purpose of this study is to examine the combined effects of 5-HTP + intense exercise on plasma and salivary cortisol levels.
Interventions
DIETARY_SUPPLEMENT5-HTP
Volunteers participate in two visits at least 5 days apart . The day of their visit they ingest (2 hours before reporting to the laboratory) either a capsule containing 200 mg of 5-HTP or a capsule containing placebo (sugar pill). The order of the visits is randomized
DIETARY_SUPPLEMENTPlacebo
Volunteers participate in two visits at least 5 days apart . The day of their visit they ingest (2 hours before reporting to the laboratory) either a capsule containing 200 mg of 5-HTP or a capsule containing placebo (sugar pill). The order of the visits is randomized
Sponsors
Benedictine University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy men and women, not taking medication known to alter glucocorticoid metabolism
Exclusion criteria
* Diabetes * Obesity * Hypertension * Coronary artery disease * Psychiatric disorders * Any disease preventing them from participating in intense exercise * Subjects taking medication known to interfere with glucocorticoid metabolism will be excluded
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in plasma cortisol from baseline to 20 minutes post | baseline, 20 min | Plasma cortisol will be assessed at baseline and 20 min post exercise and compared to baseline, and compared between treatments: 5-HTP vs placebo visit. The interventions are acute ( 1 dose, 1 day), for 5-HTP and for placebo, there is no follow up. The interventions are at least 1 week apart. For a given subject, the estimated time for study completion for the 2 treatments is 10 to 30 days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in plasma cortisol from baseline to 5 minutes post | baseline, 5 minutes | Plasma cortisol will be assessed at baseline and 5 min post exercise and compared to baseline, and compared between treatments: 5-HTP vs placebo visit. The interventions are acute ( 1 dose, 1 day), for 5-HTP and for placebo, there is no follow up. The interventions are at least 1 week apart. For a given subject, the estimated time for study completion for the 2 treatments is 10 to 30 days |
Countries
United States
Contacts
Primary ContactPedro Del Corral, PhD-MD
Outcome results
None listed