Cortisol
Conditions
Brief summary
The purpose of this study is to determine whether grapefruit juice alters the metabolism of cortisol following intense exercise.
Interventions
OTHERGrapefruit juice
Volunteers participate in two visits at least 5 days apart. The day of their visit they ingest 12.5 oz of grapefruit juice in the morning and 12.5 oz of grapefruit juice ingested in the afternoon, 3h before reporting to the laboratory. The order of the visits is randomized, one visit volunteers ingest apple juice only, the other visit grapefruit juice only
OTHERApple juice
Volunteers participate in two visits at least 5 days apart. The day of their visit they ingest 12.5 oz of grapefruit juice or Apple juice ingested in the morning and 12.5 oz of grapefruit juice ingested in the afternoon, 3h before reporting to the laboratory. The order of the visits is randomized, one visit volunteers ingest apple juice only, the other visit grapefruit juice only
Sponsors
Benedictine University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Young men and women, not taking medications known to alter glucocorticoid metabolism
Exclusion criteria
* Diabetes, uncontrolled hypertension, obesity, any medication known to interact with grapefruit juice
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Plasma cortisol change from baseline at 45 minutes | Baseline, 45 minutes | Plasma cortisol levels will be collected at baseline and 45 minutes post-exercise for the Grapefruit visit intervention and for the Apple juice intervention. The interventions are acute ( 1 day), there is no follow up. The interventions are at least 1 week apart. For a given subject, the estimated time for study completion for the 2 treatments is 14 to 30 days. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in plasma cortisol from 15 minutes to baseline | baseline, 15 minutes | Plasma cortisol levels will be collected at baseline and 15 minutes post-exercise for the Grapefruit visit intervention and for the Apple juice intervention. The interventions are acute ( 1 day), there is no follow up. The interventions are at least 1 week apart. For a given subject, the estimated time for study completion for the 2 treatments is 14 to 30 days. |
Countries
United States
Contacts
Primary ContactPedro Del Corral, PhD/MD
Outcome results
None listed