Comparison of Etomidate, Propofol and Etomidate-propofol Combination in Terms of Effects on Haemodynamic Response to Intubation

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02186990

Enrollment

Registered

2014-07-10

Start date

2014-05-31

Completion date

Unknown

Last updated

2014-08-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Induction of Anaesthesia

Brief summary

The purpose of this study is to evaluate the effect of propofol, etomidate and propofol-etomidate combination on hemodynamic responses during laryngoscopy and tracheal intubation and assess the adverse effect related to this drugs.

Interventions

DRUGpropofol

2,5 mg/kg

DRUGetomidate

0,3 mg/kg

DRUGetomidate-propofol

0,15 mg/kg etomidate + 1,25 mg/kg propofol

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* between 18 - 65 age * ASA I - II status * elective surgery

Exclusion criteria

* emergency surgery * pregnancy * alcohol and drug abuse * HT and cardiovascular disease * BMI \> 25 kg/m2 * hypersensitivity against study drug * sedative drug use in last month * difficult intubation

Design outcomes

Primary

Measure	Time frame	Description
haemodynamic values	in ten minutes after intubation	e.g., heart rate, blood pressure (mean arterial pressure)

Secondary

Measure	Time frame	Description
adverse effect of study drugs	within in 30 minutes drug administration	e.g. myoclonus, injection pain, allergy, skin rash

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026