COPD
Conditions
Keywords
exhaled breath, volatile organic compounds (VOCs), SESI-MS
Brief summary
To answer the question whether a disease specific profile of breath in patients with COPD can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.
Detailed description
This is an observational study comparing the volatile organic compounds (VOCs) in exhaled breath between COPD patients and matched control subjects (age, gender, smoking-state). 40 COPD patients (20 non-frequent, 20 frequent exacerbators) and 40 matched controls will be examined by SESI-MS on the composition of exhaled breath for identification of COPD specific markers.
Interventions
None listed
Sponsors
Swiss National Science Foundation
University of Zurich
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* confirmed COPD GOLD stage I-IV, based on a post-bronchodilator spirometry (FEV1/FVC \< 0.7) performed within the last 6 months * age between 18 and 80 years at study entry * healthy controls: normal spirometry
Exclusion criteria
* COPD exacerbation within the last 6 weeks * any lung disease other than COPD * acute inflammatory disease (e.g. common cold) within the last 6 weeks * acute or chronic hepatic disease * renal failure or renal replacement therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| COPD-specific mass spectrometric exhaled breath pattern | baseline |
Countries
Switzerland
Outcome results
None listed