Contact Lenses and Infiltrative Keratitis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02186431

Acronym

CLIK

Enrollment

Registered

2014-07-10

Start date

2014-07-31

Completion date

2016-05-31

Last updated

2016-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Keratitis

Keywords

Contact lenses

Brief summary

To quantify and compare baseline tear proteins and ocular response in contact lens wearers with a history of corneal infiltrative events, to those without a history of complications. This will be accomplished via measurement of select anti-inflammatory tear proteins before, during and after contact lens wear.

Interventions

DEVICEsenofilcon A

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* Soft contact lens wearers * Healthy (control), or with history of infiltrative keratitis (case) * Has a wearable pair of glasses * Refractive error between +8.00 D and -12.00 D, with less than 1.50 D of astigmatism

Exclusion criteria

* Smoker * Pregnant or nursing * Systemic disease that would effect tear proteins * Punctal plugs * Use of eye drops in the last week

Design outcomes

Primary

Measure	Time frame
Tear protein levels	After 4-6 hours of daily wear and after one night extended wear

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026