Dosage Calculation for Vitamin D Treatment

The Effect of Oral Loading Doses of Cholecalciferol on the Serum Concentration of 25-OH-vitamin-D

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02186106

Enrollment

Registered

2014-07-10

Start date

2012-01-31

Completion date

2013-09-30

Last updated

2014-07-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Deficiency, Vitamin D, Obesity

Brief summary

Severe vitamin D deficiency can be treated with oral loading doses of cholecalciferol. Our objective was to determine how to calculate the quantity of cholecalciferol needed for supplementation by single algorithm, usable on a patient-to-patient basis. We've conducted two studies. Study 1 was done retroactively and included 88 patients treated for low vitamin D, 60 of those with a loading dose. The second study included 29 patients and aimed to test the validity of an algorithm based on data from study 1, which included patient BMI. Both studies used oral loading doses and daily supplementation of cholecalciferol.

Interventions

DRUGCholecalciferol

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* severe hypovitaminosis D (25OH-vit.D \<25 nmol/L)

Exclusion criteria

* Malabsorption * Renal disease * Other treatment with vitamin D related products * Patients with a recent travel history with suspected increased sun exposure

Design outcomes

Primary

Measure	Time frame
Change in baseline value of [25-OH-vitamin-D]	1 week, 3 weeks and 3 months

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026