Clinical, Physiological and Prognostic Implication of Microvascular Status

Conditions

Coronary Artery Disease

Keywords

Coronary Artery Disease, Angina, Stable, Fractional Flow Reserve, Myocardial, Coronary Angiography

Brief summary

There are several physiologic parameters in evaluating cardiovascular disease. This study will reveal which parameter is the most proper value in predicting disease severity and risk factors of patients.

Detailed description

Fractional Flow Reserve (FFR), index of microcirculatory resistance (IMR), and coronary flow reserve (CFR) will be measured in stable angina patients before coronary intervention. Relationship between angiographic characteristics of patients and FFR, IMR, CFR will be analyzed. Comparison of risk factors and prognosis between parameters will be also analyzed. This study will evaluate that which parameter is correlate with disease severity and risk factors of patients.

Chung JH, Lee KE, Lee JM, Her AY, Kim CH, Choi KH, Song YB, Hahn JY, Kim HY, Choi JH, Garg S, Doh JH, Nam CW, Koo BK, Shin ES.

2020-06-2435 citations

10.1016/j.jcin.2020.04.002

Sex Differences in Long-Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluation.

Hoshino M, Hamaya R, Kanaji Y, Kanno Y, Hada M, Yamaguchi M, Sumino Y, Hirano H, Horie T, Usui E, Sugiyama T, Murai T, Lee T, Yonetsu T, Lee JM, Choi KH, Hwang D, Park J, Jung JH, Kim HY, Jung HW, Cho YK, Yoon HJ, Song YB, Hahn JY, Doh JH, Nam CW, Shin ES, Hur SH, Mejía-Rentería H, Lauri F, Goto S, Macaya F, McInerney A, Gravina G, Vera R, Gonzalo N, Jimenez-Quevedo P, Nuñez-Gil I, Salinas P, Nombela-Franco L, Del Trigo M, Fernández-Ortiz A, Macaya C, Koo BK, Escaned J, Kakuta T.

2020-02-1716 citations

10.1161/jaha.119.014458

Physiologic Characteristics and Clinical Outcomes of Patients With Discordance Between FFR and iFR.

Lee SH, Choi KH, Lee JM, Hwang D, Rhee TM, Park J, Kim HK, Cho YK, Yoon HJ, Park J, Song YB, Hahn JY, Doh JH, Nam CW, Shin ES, Hur SH, Koo BK.

2019-09-2551 citations

10.1016/j.jcin.2019.06.044

Prognostic Implication of Thermodilution Coronary Flow Reserve in Patients Undergoing Fractional Flow Reserve Measurement.

Lee JM, Choi KH, Hwang D, Park J, Jung JH, Kim HY, Jung HW, Cho YK, Yoon HJ, Song YB, Hahn JY, Doh JH, Nam CW, Shin ES, Hur SH, Koo BK.

2018-08-0147 citations

10.1016/j.jcin.2018.05.005

Coronary Flow Reserve and Microcirculatory Resistance in Patients With Intermediate Coronary Stenosis.

Lee JM, Jung JH, Hwang D, Park J, Fan Y, Na SH, Doh JH, Nam CW, Shin ES, Koo BK.

2016-03-01252 citations

10.1016/j.jacc.2015.12.053

Integrated Physiologic Assessment of Ischemic Heart Disease in Real-World Practice Using Index of Microcirculatory Resistance and Fractional Flow Reserve

Joo Myung Lee, Jamie Layland, Ji-Hyun Jung, Hyun‐Jung Lee, Mauro Echavarría‐Pinto et al. (15 authors)

Circulation Cardiovascular Interventions2015-10-24121 citations

10.1161/circinterventions.115.002857

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Age ≥ 18 * Patients with stable angina * FFR, IMR, CFR were measured before coronary intervention

Exclusion criteria

* Patients who have severe side effects or contraindication to hyperemic agents (ex. adenosine) * Patients with hemodynamic instability * elevation of cardiac enzymes, evidence of acute MI, or a culprit vessel of acute coronary syndrome

Design outcomes

Primary

Measure	Time frame
Spearman correlation coefficient between FFR, IMR, CFR and angiographic severity	during coronary angiography

Countries

South Korea

Contacts

Primary ContactJoo Myung Lee, MD, MPH, PhD

drone80@hanmail.net82-10-8884-8439

Backup ContactBon-Kwon Koo, MD, PhD

bkkoo@snu.ac.kr82-2-2072-2062

Outcome results