Female Infertility Due to Diminished Ovarian Reserve
Conditions
Keywords
Poor responders, Poor ovarian response, IVF/ICSI, Microflare protocol, Growth hormone, Oral contraceptive pills
Brief summary
The effect of use of the microflare down regulation protocol on the outcome of the IVF/ICSI cycles in poor responders
Detailed description
The microflare as a method of down regulation protocol can be used to prepare the females suffering from poor ovarian reserve to undergo IVF/ICSI cycles. In this study we are trying to outline its effect on the clinical pregnancy rate as a main primary outcome, and to compare its use with the addition of growth hormone to the same protocol.
Interventions
Growth hormone (Norditropin, Novo nordisk) was administrated on day 6 of HMG stimulation daily in a dose of 2.5 mg S.C. till the day of hCG administration.
Sponsors
Woman's Health University Hospital, Egypt
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* females fulfilling the criteria of the ESHRE consensus 2011: At least two of the following three features must be present: (i) Advanced maternal age (≥40 years) or any other risk factor for POR; (ii) A previous POR (≤3 oocytes with a conventional stimulation protocol); (iii) An abnormal ovarian reserve test (i.e. AFC ,5-7 follicles or AMH ,0.5 -1.1 ng/ml).
Exclusion criteria
* women who suffer from any other cause of infertility other than poor ovarian reserve * refusal of the patient to consent for using her data in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rates | 15 months |
Countries
Egypt
Outcome results
None listed