Atrophic Gastritis
Conditions
Keywords
atrophic gastritis, pepsinogen, Helicobacter pylori
Brief summary
It is well-known that atrophic gastritis is a major risk factor for gastric cancer, which leads to variations in the serum levels of gastrin, pepsinogen (PG) I, and PGII. We want to assess the effects of age, sex, and Helicobacter pylori status on pepsinogen (PG) level for atrophic gastritis and whether gastric atrophy based on the PG test would be improved after H. pylori eradication.
Interventions
DRUGpepsinogen and gastrin
Sponsors
Yonsei University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. over 19 years 2. the patients who have gastrointestinal discomfort or get esophagogastroduodenoscopy (EGD) for health check up 3. the patients who got the procedure, endoscopic submucosal resection (ESD) for early gastric cancer
Exclusion criteria
1. gastrectomy history 2. advanced gastric cancer (impossible to get the gastrectomy) 3. Helicobacter eradication history 4. the patients who have chronic disease 5. cancer patients except gastric cancer within 6 months 6. who cannot perform this study according to research's decision 7. who have bleeding tendency (ex. taking antiplatelet agent, low platelet count or abnormal coagulation time)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the change of pepsinogen level before and after H. pylori eradication | baseline and 6 months | to compare the change of the pepsinogen level before and after H. pylori eradication and evaluate the correlation between the pepsinogen level and the atrophic gastritis |
Countries
South Korea
Contacts
Primary ContactYong Chan Lee, MD, PhD
Outcome results
None listed