Anthropometric Measure, Blood Pressure, Insulin Resistance, Lipid Profile, Oxidative Stress
Conditions
Brief summary
Our aim was to assess the effects of a hypocaloric diet, including diet fruit jelly with microencapsulated fish oil or conjugated linoleic acid or placebo, on anthropometry, body composition, insulin resistance and lipid profile in women with metabolic syndrome and genotype Pro12Pro in the PPAR gamma 2 gene.
Interventions
DIETARY_SUPPLEMENTmicroencapsulated conjugated linoleic acid
The microencapsulated conjugated linoleic acid received light fruit jam with microencapsulated conjugated linoleic acid (3 g/day) during 12 weeks.
DIETARY_SUPPLEMENTmicroencapsulated fish oil
The microencapsulated fish oil group received light fruit jam with microencapsulated fish oil (3 g/day) during 12 weeks.
DIETARY_SUPPLEMENTlight fruit jam
The placebo group received light fruit jam (15 g/day) during 12 weeks.
Sponsors
Rio de Janeiro State Research Supporting Foundation (FAPERJ)
Universidade Federal do Rio de Janeiro
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
30 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* adults women (30-45 years old); * diagnosis of metabolic syndrome, as defined by the International Diabetes Federation; * Pro12Pro genotype in gene PPARγ2.
Exclusion criteria
Participants were excluded if they: * Were allergic to strawberries or fish * Were pregnant or lactating * Took fatty acid supplements * Had undergone bariatric surgery or were being treated nutritionally or pharmacologically for reducing BM, or had taken anti-obesity drugs during the previous three months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oxidative stress biomarker | Change from baseline at 12 weeks | Plasma malondialdehyde levels |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Insulin resistance | Change from baseline at 12 weeks | Homeostatic Model Assessment-Insulin Resistance index, adiponectin, glucose and insulin levels |
| Lipid profile | Change from baseline at 12 weeks | Total cholesterol, LDL-cholesterol, VLDL-cholesterol, HDL-cholesterol and triglycerides serum levels and EPA, DHA and total conjugated linoleic acid plasma levels |
| Anthropometric measures | Change from baseline at 12 weeks | Body weight, body mass index and waist circumference |
| Body composition measures | Change from baseline at 12 weeks | Fat-free mass and fat mass |
| Blood pressure | Change from baseline at 12 weeks | Systolic blood pressure and diastolic blood pressure |
Countries
Brazil
Outcome results
None listed