Pre-dinner vs. Post-dinner Exercise on Glycemic Control

Exercise Timing and Postprandial Glycemia in Type 2 Diabetes

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02180620

Enrollment

Registered

2014-07-02

Start date

2013-09-30

Completion date

2014-04-30

Last updated

2017-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes

Keywords

GIP, GLP-1, exercise timing, resistance exercise, glucose concentrations

Brief summary

With many medications we prescribe them relative to time of day or a meal. This study established if pre dinner vs post dinner exercise was more effective at altering post dinner glucose and triglyceride levels vs no exercise at all.

Detailed description

All participants completed three trials in a random order in which they consumed a standardized dinner meal with 1) no RE (NoRE), 2) pre-dinner RE (RE→M), and 3) post-dinner RE beginning 45 min after dinner (M→RE). Diet was standardized during the day of testing. Participants reported to the lab for testing sometime between 3 - 5:30 p.m. and upon arrival a venous catheter was inserted into a forearm vein. Frequent blood sampling, indirect calorimetry measurements, and subjective well-being measurements ensued for \ 5.75 h while the participants were in the lab.

Interventions

OTHERNo exercise

During the no exercise trial (NoEX), the participants will remain sedentary during testing.

OTHERMeal then exercise

During the post-meal exercise trial (M→EX), 45 min of resistance training will be performed

OTHERexercise then meal

During the exercise prior to the meal trial (EX→M), 45 min of resistance training will be performed

Study design

Allocation

NON_RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

25 Years to 55 Years

Healthy volunteers

Inclusion criteria

* Obese ( body mass index 30-45 kg/m2) * Physician diagnosed with type 2 diabetes receiving standard medical care * Non-smokers * Pregnancy * Lactating mothers

Exclusion criteria

* Insulin * Surgical weight loss * Orthopedic limitations to exercise * Weight loss in the previous 3 months

Design outcomes

Primary

Measure	Time frame
glucose concentrations	Blood samples were taken every 5-10 min during the first 3.7 h of testing and every 30 min during the last 2 h

Secondary

Measure	Time frame
triglyceride concentrations	Blood samples were taken every 5-10 min during the first 3.7 h of testing and every 30 min during the last 2 h

Other

Measure	Time frame
GLP-1 concentrations	Blood samples were taken every 5-10 min during the first 3.7 h of testing and every 30 min during the last 2 h

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026