Acne
Conditions
Keywords
acne, lipid, tretinoin, isotretinoin
Brief summary
The purpose of this study is to evaluate the differences in the skin lipid profile of patients with and without acne. Secondly, the goal is to learn more about what the effects of retinoinds (topical and systemic) are on the the skin lipid profile. We hypothesize that the skin lipid profile of subjects with acne will be lower in inflammatory lipids in comparison to subjects without acne.
Detailed description
Skin lipid profile will be conducted via sebutapes- adhesive tapes that painlessly absorbs sebum from the face. These tapes will be placed on the face for 1 hour. A photograph of the face will be taken during each study visit. A sebumeter will also be used to measure skin sebum secretion rate.
Interventions
DRUGTretinoin or Adapalene
Subjects will apply a pea sized amount of topical retinoid cream once daily at night for 30 days. Subjects will return for a follow-up visit.
DRUGIsotretinoin
Subjects will take one pill once daily for 5 months. Subjects will return after 1 month and after 4-5 months of treatment for skin lipid profiling.
Sponsors
University of California, Davis
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
12 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* age 12 to 30 years * have been prescribed tretinoin OR isotretinoin
Exclusion criteria
* those who have taken isotretinoin (systemic) * those who used tretinoin or other topical retinoid within two weeks of starting the study * those with seborrheic dermatitis, rosacea, or polycystic ovary syndrome * those who are pregnant, prisoners, or cognitively impaired * those who do not fit the inclusion criteria
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Skin lipid profile of acne and healthy patients | baseline visit | Compare the skin lipid profile of acne and healthy patients at baseline |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Skin lipid profile of acne patients after treatment | at 1 month and 4-5 months of treatment | Patients in the topical retinoid group will have their lipids evaluated after 1 month of treatment. Patients in the systemic retinoid (isotretinoin) group will have their lipids evaluated after 1 and 4-5 months of treatment. |
Countries
United States
Outcome results
None listed