Obesity, Type 2 Diabetes Mellitus
Conditions
Keywords
Gut microbiota
Brief summary
An altered gut microbiota composition has recently been linked to obesity and diabetes. The principal aim of this study was to investigate and compare the gut microbiota composition of obese, diabetic and control individuals. Then, associations between analyzed gut microbial concentrations and clinical-biochemical blood parameters were assessed.
Interventions
OTHERComparison of the gut microbiota composition
Sponsors
Gulhane School of Medicine
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Subjects with obesity or newly diagnosed type 2 diabetes * 18 years to 65 years of age
Exclusion criteria
* Any chronic disease (other than obesity and diabetes) * Alcohol consumption/smoking * Pregnancy/breastfeeding * The use of antibiotics, pro-prebiotics within 3 months * \<18 years or \>65 years * History of intestinal surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The comparison of the gut microbiota composition | 9 months | The gut microbiota composition of obese, diabetic and control individuals was analyzed by quantitative real-time PCR (qRT-PCR) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The relationship between metabolic parameters and the gut microbiota composition | 9 months | A multivariate linear regression analysis was performed in order to test associations between the gut microbiota composition and metabolic variables of participants |
Countries
Turkey (Türkiye)
Outcome results
None listed