Predicting Normal vs. Carrier Status in Euploid Embryos of Translocation Carriers

Evaluation of the Accuracy of Predicting Normal or Carrier Status in Euploid Embryos Produced by Patients With Balanced Translocations

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02178865

Enrollment

Registered

2014-07-01

Start date

2014-06-30

Completion date

2017-02-28

Last updated

2017-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Balanced Chromosomal Translocation

Keywords

translocation

Brief summary

The purpose of this study is to assess the accuracy of predicting the normal or carrier status of human embryos resulting from in vitro-fertilization (IVF) from patients carrying a balanced translocation.

Detailed description

This study aims to evaluate the validity of using informative SNPs to distinguish balanced from normal embryos. This will involve acquiring material from families to set phase for informative SNPs, evaluation of existing and new embryo SNP array data, and follow up analysis of children born after applying the procedure.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

7 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* patients with balanced translocations who have undergone IVF

Exclusion criteria

* those who do not wish to know their child(s) karyotype

Design outcomes

Primary

Measure	Time frame
Proportion of correct predictions of normal vs. balanced ploidy status as compared to conventional karyotype	up to 12 months once pregnant

Countries

United States

Outcome results