Gingivitis
Conditions
Keywords
Gingivitis
Brief summary
There is a need for toothpastes that more effectively remove oral plaque and prevent re-formation. The objective of this study is to map the development and resolution of clinical gingivitis using conventional clinical examination and imaging data to determine how useful imaging techniques can be for evaluating how well a toothpaste cleans the teeth
Detailed description
The researcher can use imaging techniques to map changes in gingival blood flow during the development and resolution of fully reversible, early clinical gingivitis using standard-of-care clinical indices as gold standard The researcher can use imaging techniques to map inflammatory microstructural changes in the oral mucosa including swelling, vasodilation and edema during the development and resolution of fully reversible, early clinical gingivitis using standard-of-care clinical indices as gold standard
Interventions
DEVICEoptical measurements
Laser Speckle Imaging, Optical Coherence Tomography and Multiphoton Microscopy
Sponsors
Beckman Laser Institute University of California Irvine
University of California, Irvine
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 25 Years
Healthy volunteers
No
Inclusion criteria
* Adult male or female 18-25 years of age * Volunteers with gingivitis but no periodontitis
Exclusion criteria
* Subjects who must receive dental treatment during the study dates. * History of significant adverse effects following use of oral hygiene products such as toothpastes and mouth rinses. Allergy to personal care/consumer products or their ingredients. * Individuals who have taken antibiotics in the previous 3 months * Individuals who are pregnant or nursing
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in gingival perfusion | up to 6 weeks | optical measurements |
Countries
United States
Outcome results
None listed