Infection of Cesarian Section Wound Following Delivery
Conditions
Keywords
Elective Cesarean Section, Antibiotic prophylaxis, Timing of Antibiotic prophylaxis, post cesarean section infection
Brief summary
A randomized controlled study comparing the effect of administration of 1 gm ceftriaxone in elective cesarean section 30-60 min before skin incision versus after cord clamping.
Detailed description
comparing the effect of administration of 1 gm ceftriaxone in elective cesarean section 30-60 min before skin incision versus after cord clamping.on post-cesarean section infection(wound infection as a primary outcome)
Interventions
DRUGceftriaxone 1gm for intravenous infusion
Patients undergoing elective cesarean section with Gestational age 37 weeks or more. comparing the effect of administration of 1 gm ceftriaxone in elective cesarean section 30-60 min before skin incision versus after cord clamping.on post-cesarean section infection(wound infection as a primary outcome)
Sponsors
Ain Shams Maternity Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing elective cesarean section with Gestational age 37 weeks or more
Exclusion criteria
1. Fever greater than 38°C or maternal sepsis. 2. Cephalosporin allergy. 3. Exposure to any antibiotic agent within 1week before delivery. 4. Patents having premature rupture of membranes and acute chorioamnionitis. 5. Patients with chronic diseases (diabetes mellitus, renal disease and Cardiac disease). 3\) Morbid obesity (BMI\>30)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The primary outcome is the rate of post cesarean section surgical site infection. | administration of 1gm ceftriaxone prophylaxis for elective cs and follow up surgical site infection till 40 days | postoperative assessment of SSI. Patients will be followed up at 48-72 hours postoperative, at 7th days (skin suture removal) and at 6 weeks (contraception application).all patients will be contacted by telephone and interviewed. They will be rescheduled for a clinic visit if they reported signs and symptoms of wound infection (purulent discharge or erythema \>1 cm in diameter, induration of the incision site and fever). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| other post cesarean section maternal and neonatal infection | follow up ofother post cesarean section maternal and neonatal infection till 40 days of delivery | 1. Maternal complications: other post cesarean section maternal complications, namely endometritis, pyrexia, urinary tract infection and complication of drug administration such as anaphylaxis. 2. Neonatal complications: such as neonatal sepsis |
Countries
Egypt
Outcome results
None listed