Quantitative Determination of Brain Water Content in Patients During and After Hepatic Encepalopathy

Quantitative Determination of Brain Water Content in Patients During and After Hepatic Encepalopathy Measured by MR

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02177708

Enrollment

Registered

2014-06-30

Start date

2014-01-31

Completion date

2015-12-31

Last updated

2014-06-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatic Encephalopathy

Brief summary

There is increasing evidence that the pathophysiology of hepatic encephalopathy (HE) is tightly associated with low-grade cerebral edema. Uptake of ammonia in astrocytes leads to osmotic swelling caused by glutamine formation. Previous studies were performed in covert HE patients or used indirect methods. Methods: The investigators wish to describes quantitative measurement of localized water content using MRI water mapping in a cohort of patients with cirrhosis during an episode of overt HE type C and again after recovery. Furthermore patients with cirrhosis and no history of HE and healthy subjects will be investigated as controls.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients with type C HE during and after HE, * Patients with stable cirrhosis and * Healthy subjects

Exclusion criteria

* Patients with pace-maker * Metal implants

Design outcomes

Primary

Measure	Time frame
Absolute brain water content measured by water mapping	Patients are recruited during an episode of acute HE, the patients are rescanned within a time frame of 6 weeks. Patients with stable cirrhosis and healthy subjects are scanned only once.

Countries

Denmark

Outcome results