Magnetic Resonance Imaging in Myocarditis

Myocarditis and the Role of Advanced Magnetic Resonance Imaging

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02177630

Acronym

MyoRacer

Enrollment

129

Registered

2014-06-27

Start date

2012-08-31

Completion date

2015-12-31

Last updated

2021-05-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocarditis

Keywords

myocarditis, myocardial inflammation, imaging, magnetic resonance

Brief summary

The purpose of this study is the assess the diagnostic performance of magnetic resonance imaging in patients with suspected myocarditis by applying different imaging sequences at different MR scanners

Detailed description

In patients with clinical suspicion of myocarditis biventricular endomyocardial biopsy is performed for definite diagnosis. In addition, patients undergo magnetic resonance imaging at 1.5 Tesla and 3.0 Tesla within 24 hours. The imaging protocol of both scan include assessment of myocardial edema respectively edema ratio; myocardial hyperemia respectively global relative enhancement (gRE); myocardial fibrosis/necrosis respectively myocardial LE and T1 and T2 mapping sentences. Diagnostic performance of different imaging protocols as compared to the findings of endomyocardial biopsies is calculated. The protocol also includes a follow-up MR can at 3 months.

Interventions

OTHEREndomyocardial Biopsy

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

Symptoms such as: * Dyspnea or Orthopnea or * Palpitations or * Exercise intolerance or * Angina Evidence of myocardial involvement: * ventricular dysfunction on echocardiography or * new or persistent ECG changes * elevated Troponin T History of viral infection

Exclusion criteria

* Contraindication for magnetic resonance imaging * Impaired renal function: glomerular filtration rate ≤ 30 ml/min/m2 * Patients presenting with pregnancy * Patients without informed consent * Participation in another trial.

Design outcomes

Primary

Measure	Time frame	Description
Accuracy, sensitivity and specificity of magnetic resonance imaging sequences	baseline	The diagnostic accuracy of individual and a combination of MR imaging sequences (late enhancement images, assessment of global edema, relative enhancement and T1 and T2 mapping sequences) will be determined by comparison to endomyocardial biopsies, which serve as diagnostic gold-standard

Secondary

Measure	Time frame
Diagnostic performance of biventricular endomyocardial biopsies	baseline

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 13, 2026