Acute Myeloid Leukemia, Diagnosis, Iron, Oxydative Stress
Conditions
Brief summary
In this study, the investigators study the prognostic role of oxidative stress metabolism and iron in Acute myeloid leukemia.
Detailed description
Primary goal of this study is to Evaluate the characteristics of regulatory networks of iron and redox balance in leukemic cells, to study the correlations between the prognosis of AML patients (in terms of response to induction chemotherapy and survival i) and metabolism of these markers. Secondary ones areto assess the impact of induction therapy on markers of oxidative stress and to correlate biological iron and redox metabolism with the molecular status of patients (eg Flt3/IDH/CEBPA/NPM...). Eligibility criteria are patients at diagnostic of de novo acute myeloid leukemia (promyelocytic excluded) aged from 18 to 100 years.
Interventions
None listed
Sponsors
University Hospital, Grenoble
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
de novo acute myeloid leukemic patient from 18 years to 99 years at diagnosis
Exclusion criteria
age under 18 years promelocytic leukemia secondary leukemia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall survival Event-free survival Response to induction chemotherapy, overalll survival, event-free survival | five years after the inclusion |
Countries
France
Contacts
Primary Contactpascal mossuz, phd
Outcome results
None listed