Bariatric Surgery Candidate, Obesity, Physical Activity
Conditions
Keywords
Obesity, Bariatric surgery, physical activity, cardiopulmonary exercise test
Brief summary
Obesity is a growing problem worldwide and its prevention has become one of the leading priorities for the World Health Organisation. Obesity results from chronic imbalance between energy intake and energy expenditure. Although early prevention of obesity is preferable, surgical treatment is often required for severely obese people. Bariatric surgery has been shown to be the most effective therapy for severe obesity. Weight loss following bariatric surgery results in significant improvements in coexisting comorbidities, such as diabetes and hypertension but there is controversy whether bariatric surgery also improves aerobic capacity. The purpose of this study is to investigate the effects of bariatric surgery on cardiopulmonary function and on daily physical activity. It is hypothesized that bariatric surgery will improve aerobic capacity and result in beneficial lifestyle changes from sedentary to more active.
Interventions
None listed
Sponsors
Universidade Federal do Triangulo Mineiro
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
St George's, University of London
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Ages 18 years to 50 years * Patients enrolled in the bariatric surgery program of St George's Hospital with BMI \> 40 kg/m2, or 35-40 kg/m2 in the presence of other obesity-related comorbidities such as hypertension or type- 2 diabetes
Exclusion criteria
* Locomotor difficulties which would prevent participants from completing the cardiopulmonary exercise testing * Weight \> 190 kg (due to weight restrictions of equipment used to transfer patients in the event of medical emergencies) * Cognitive impairment * Patients unable to follow instructions in English
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiorespiratory function assessed by peak oxygen consumption (VO2peak) | One to two weeks before surgery and six months after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lung function | One to two weeks before surgery and six months after surgery | Lung function will be assessed by spirometry and body plethysmography |
| Heart function | One to two weeks before surgery and six months after surgery | Echocardiography will be performed to assess heart function. |
| Inspiratory muscle strength | One to two weeks before surgery and six months after surgery | Maximal inspiratory pressure and sniff nasal pressure will be recorded. |
| Peripheral muscle strength | One to two weeks before surgery and six months after surgery | Maximum isometric strength of hand/ forearm, quadriceps and hip flexors muscles will be evaluated |
| Free living sedentary and physical activity times | One to two weeks before surgery and six months after surgery | Daily physical activity habits will be assessed by an accelerometer and International Physical Activity Questionnaire: Long (IPAQ-Long). Participants will be required to wear the accelerometer for four consecutive days during the two study points. |
Countries
United Kingdom
Contacts
Primary ContactDimitra Nikoletou, PhD
Outcome results
None listed