Cocaine Use Disorder
Conditions
Keywords
Cocaine use disorder
Brief summary
The investigators are conducting a randomized clinical trial of rapid abstinence initiation and cognitive control training as a precursor to our new web-based version of the CBT4CBT (Computer Based Training for Cognitive Behavioral Therapy) program to evaluate its effectiveness relative to standard outpatient counseling at the Midwestern Connecticut Council of Alcoholism (MCCA). CCT will be used to assess attention, working memory and inhibitory control and the computer-based training program (CBT4CBT) focuses on teaching basic coping skills, presenting examples of effective use of coping skills in a number of realistic situations in video form, and providing opportunities for patients to practice and review new skills while receiving cocaine abuse treatment.
Detailed description
150 cocaine dependent individuals will be randomly assigned to one of 3 conditions delivered over 4 weeks in the context of intensive outpatient treatment. 1. Treatment as Usual (TAU), 2. rapid abstinence initiation (RAI) or 3. computerized cognitive control training with escalating reinforcement for improved performance on training tasks (CCT). All participants will then receive an 8 week trial of CBT4CBT in addition to TAU. Follow up evaluation thru 6 months posttreatment will assess durability and delayed emergence of treatment effects.
Interventions
BEHAVIORALTreatment As Usual (TAU)
Treatment normally offered at this clinic which could include individual or group drug counseling sessions three times per week lasting three hours each time.
BEHAVIORALTAU plus Rapid Abstinence Initiation (RAI)
Treatment normally offered at this clinic which could include individual or group drug counseling sessions three times per week lasting three hours each time PLUS the chance to earn money for urine specimens that are negative for cocaine during the first 4 weeks of treatment followed by 8 weeks of CBT4CBT computerized therapy.
BEHAVIORALTAU plus RAI plus Cognitive Control Training (CCT)
Treatment normally offered at this clinic which could include individual or group drug counseling sessions three times per week lasting three hours each time PLUS the chance to earn money for urine specimens that are negative for cocaine during the first 4 weeks of treatment PLUS sessions of computerized cognitive control training (CCT) 3 times per week for the first 4 weeks followed by 8 weeks of CBT4CBT computerized therapy.
Sponsors
National Institute on Drug Abuse (NIDA)
Yale University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 18 years of age or older * Meet current DSM-5 criteria for cocaine use disorder * Are sufficiently stable for 12 weeks of outpatient treatment * Are willing to provide locator information for follow-up * Are fluent in English * Have a 6th grade or higher reading level for completion of assessments
Exclusion criteria
* Untreated bipolar or schizophrenic disorder * Current suicide risk * Have a legal case pending such that incarceration during the 12-week protocol is likely * Are physically dependent on alcohol, opioids or benzodiazepines and require detoxification
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reduction in cocaine use | 12 weeks | Using urine and breathalyzer screening for negative cocaine and alcohol testing. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Subjects ability to demonstrate coping skills acquisition through a computerized role-playing evaluation | 12 weeks | Use of CBT4CBT program with acquisition of skills demonstrated through homework assignments. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Increased cognitive function and working memory | 12 weeks | development of skills used in attention, working memory and inhibitory control as demonstrated through an extensive assessment battery. |
Countries
United States
Outcome results
None listed