Bladder Cancer
Conditions
Keywords
bladder cancer, conduit diversion, orthotopic neobladder, health-related quality of life, validated questionnaire
Brief summary
The aim of this study is to compare the health-related quality of life (HRQoL) between patients underwent conduit diversion and orthotopic neobladder after radical cystectomy. The investigators plan to use validated HRQoL questionnaires to learn about how the different urinary diversion operations affect the HRQoL of people living with bladder cancer. The findings from this study may help doctors and patients choosing the proper operation type.
Interventions
BEHAVIORALvalidated health-related quality of life questionnaires
All eligible patients who agree to participate will be asked to fulfill three different validated health-related quality of life questionnaires (EORTC-QLQ-C30/BLM, FACT-BL and BCI) prior to surgery and at 3, 6, 12, 18 months postoperatively.
Sponsors
Huazhong University of Science and Technology
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of muscle invasive bladder cancer * Must be scheduled for radical cystectomy and subsequent conduit diversion or orthotopic neobladder * Must be able to provide informed consent * Must be 18 years of age or older * May have had received intravesical neoadjuvant, adjuvant chemotherapy or immunotherapy
Exclusion criteria
* Follow-up data not obtained at Wuhan Union Hospital
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline in HRQoL of bladder cancer patients with different types of urinary diversions | Preoperative baseline and 3, 6, 12, 18 months postoperatively |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Score differences between the two groups of patients in the relevant domains from three various validated tools of HRQoL | Preoperative baseline and 3, 6, 12, 18 months postoperatively | The aim is to compare three various validated tools of HRQoL to study their relative contributions in accounting for variance in prediction of patient HRQoL. The three validated tools of HRQoL are EORTC-QLQ-C30/BLM (The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire/bladder cancer module), FACT-BL (Functional Assessment of Cancer Therapy-Bladder cancer) and BCI (Bladder Cancer Index). The two groups are conduit diversion group and orthotopic neobladder group. |
| Score changes of each patient group during the follow-up | Preoperative baseline and 3, 6, 12, 18 months postoperatively | Longitudinally learn about the changes of each individual patient HRQoL after urinary diversion and compare the changes of two groups, i.e. conduit diversion group and orthotopic neobladder group. |
| Objective examination outcomes | Preoperative baseline and 3, 6, 12, 18 months postoperatively | Supplement the assessment by interviewing the patients with some lab and image examinations, such as renal function tests, liver function tests, urine culture, urine cytology, chest radiography, ultrasound of kidney, ureter and bladder (KUB) etc. |
Countries
China
Contacts
Primary ContactXiaoping Zhang, MD, PhD
Backup ContactHangchuan Shi, MD
Outcome results
None listed