Leptin and Visfatin in Diabetic Patients With Periodontitis Before and After Periodontal Therapy

Effect of Non-surgical Periodontal Therapy on Leptin and Visfatin Expression in Gingival Tissues of Chronic Periodontitis With and Without Type 2 Diabetes Mellitus: A Study Utilizing ELISA and Real Time PCR

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02174146

Enrollment

Registered

2014-06-25

Start date

2013-09-30

Completion date

2013-12-31

Last updated

2014-06-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Periodontitis, Type 2 Diabetes Mellitus

Keywords

leptin, visfatin, chronic periodontitis, diabetes mellitus, non-surgical periodontal therapy

Brief summary

1. Are adipokines involved in pathogenesis of periodontal disease in diabetic patients? 2. Does their level change after periodontal therapy?

Detailed description

Patients with chronic periodontitis only and patients with chronic periodontitis and diabetes were evaluated for levels of leptin and visfatin in the gingival tissues before and after non-surgical periodontal therapy.

Interventions

PROCEDUREnon-surgical periodontal therapy

supra and subgingival debridement

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

35 Years to 54 Years

Healthy volunteers

Yes

Inclusion criteria

* diabetic patients having diabetes mellitus ≥5 years prior to the study. * chronic periodontitis with clinical attachment loss \> 5 mm. * otherwise systemically healthy subjects.

Exclusion criteria

* any known systemic diseases other than diabetes. * pregnancy or lactation. * smokers. * receiving periodontal treatment in the last 6 months. * taking any drugs or medications other than anti-diabetic drugs.

Design outcomes

Primary

Measure	Time frame	Description
visfatin levels in gingival tissues	3 months	estimation of protein and gene expression of visfatin in patients with chronic periodontitis only and diabetic patients with periodontitis before and after non-surgical periodontal therapy..
leptin levels in gingival tissue	3 months	estimation of protein and gene expression of leptin in patients with chronic periodontitis only and diabetic patients with periodontitis before and after non-surgical periodontal therapy..

Secondary

Measure	Time frame	Description
pocket depth	3 months	estimation of pocket depth in patients with chronic periodontitis only and diabetic patients with periodontitis before and after non-surgical periodontal therapy.
clinical attachment level	3 months	estimation of clinical attachment level in patients with chronic periodontitis only and diabetic patients with periodontitis before and after non-surgical periodontal therapy.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026